Credits: 0.5 Offered: Spring 2
This semesterly-offered course will aim to inform and instruct students on the process of applying for a predoctoral fellowship. Students will learn the different funding mechanisms available to them for a fellowship and will ultimately prepare sev- eral components of the NRSA application with the intent of submission. The subject matter will include strategies for building a highly competitive application by thoroughly analyzing the scored review criteria: Fellowship Applicant; Sponsors, Collaborators, and Consultants; Training Potential; Institutional Environment and Commitment to Training; and Research Training Plan. It will also include strategies for converting a completed Thesis Proposal into the analogous documents for fellowship applications. The course will primarily focus on the application for an NRSA F30/31 award but will be applicable for students targeting other granting mechanisms that have the same components. Homework assignments will aid in the preparation of a fellowship application and will, therefore, keep students on pace for the current submission cycle.
Prerequisites: Successfully having passed your Thesis Proposal Exam with the intention to submit a fellowship application by the end of the semester.
Grading Policy: Pass/Fall
Credits: 1 Offered: Spring 2
Emerging Zika and Ebola viruses caused the two most recent crises in global public health. More and more novel viral threats are discovered and old viral threats are re-emerging. This course will discuss important emerging and re-emerging viruses and their biology, pathogenicity and prevalence. We will also focus on novel prophylactic (vaccines) and therapeutic technologies that are under development to combat these viruses. The course will cover orthomyxoviruses (influenza), paramyxoviruses (Nipah, Hendra etc.), flaviviruses (dengue, Zika etc.), alphaviruses (Chikungunya etc.), bunyaviruses (hantaviruses, CCHFV etc.), filoviruses (Marburg virus, ebolaviruses), coronaviruses (SARS-CoV, MERS-CoV) and others.
Credits: 1 Offered: Spring 2
The objective of this elective is to provide students with advanced training in an area of interest to them in support of dissertation research and their long-term career development. As part of this elective, students are required to participate in an internship of their choosing and that has prior approval by the student’s dissertation advisor and the course directors. Students are required to provide periodic oral update reports of their progress in the internship (the frequency of these will be determined by the length of the internship) and a final paper summarizing the internship.
Credits: 1 Offered: Spring 2
The objective of this elective is to provide students with advanced training in an area of interest to them in support of dissertation research and their long-term career development. As part of this elective, students are required to participate in an internship of their choosing and that has prior approval by the student's dissertation advisor and the course directors. Students are required to provide periodic oral update reports of their progress in the internship (the frequency of these will be determined by the length of the internship) and a final paper summarizing the internship.
Credits: 3 Offered: Spring 2
Research Credit for Independent Research. Only PhD and MD/PhD in Biomedical Science or Neuroscience, who have NOT passed the Thesis Proposal should register for this course
Credits: 0 Offered: Spring 2
This course is open to 3rd year MSBS students who are working full-time in a lab during the Spring semester to complete their master's thesis. The course is graded Pass/Fail. Tuition is not charged for this course.
Credits: 0 Offered: Spring 2
For visiting students/scholars only
Credits: 5 Offered: Fall
All First Year MD-PhD students should register for this course
Credits: 5 Offered: Fall
All Second Year MD-PhD students should register for this course
Credits: 1 Offered: Fall
This course covers the journey from nanotherapeutic design to clinical approval. We will focus on nanomaterial synthesis and characterization, techniquest to monitor their in vivo behavior and efficacy, the design of therapeutic studies, and the translation from small to large animals and humans. We will discuss the basic principles of the application of nanomedicine, exemplified by state-of-the art technologies and recent research studies. The course will also include a tour of the Biomedical Engineering and Imaging Institute's Nanomedicine Laboratory and Imaging facilities.
Credits: 1 Offered: Fall
As Artificial Intelligence (AI) and Machine Learning (ML) become increasingly applied in biomedical sciences, it is critical that trainees, researchers, and clinicians are made aware of both technical and ethical issues related to AI. In this course we will start with review of the terminology in AI-based tools and key networks being used in medical applications, such as medical imaging, regression analysis and time prediction. We will understand key works published in the space, be able to critically assess their contribution, as well as their clinical value. A key factor in making AI successful is the correct definition and use of Data. We will review how data must be defined, extracted, and structured for the effective application of AI & ML. Making the data Findable, Accessible, Interoperable, and Reusable (FAIR), is a key factor in building strong network models that can be used in the clinic. Additional attention will be given to bias and ethical issues that need to be addressed in the development of the models and in their clinical testing. Overall, we will cover the variety of challenges that must be overcome for AI to reach its full potential.
Credits: 4 Offered: Fall
Laboratory rotations are an important part of the first year of the Graduate Program at Mount Sinai. They give students the opportunity to experience different research projects, different laboratory and mentoring styles, and allow the faculty to assess the interests and aptitude of the students. All PhD and MD-PhD students will complete laboratory rotations (two are recommended) before declaring a research preceptor and a Multidisciplinary Training Area. PhD Students must complete their lab rotation agreements and monthly check-in forms to record their rotation status and in order to pass this course.
Credits: 6 Offered: Fall
Biomedical Science - Fall is part 1 of a year long six unit course that surveys a broad and comprehensive study of basic Molecular Cellular and Developmental Biology. The topics covered prepare students for both a career in Biomedical Research and for the Advanced studies within the CAB, DSCB, GGS, IMM, and MIC MTAs. Biomedical Science is a required course for all first year students that intend to be members of these MTAs. The course is structured as a series of lectures; grade assessment is based on a mixture of in-class and take home quizzes as well as one formal examination per unit
Credits: 8 Offered: Fall
Biomedical Science - Fall for MDPhD students. 1st year MD-PhD students must register for this course.
Credits: 0.5 Offered: Fall
This course is required for all first-year graduate students, following NIH mandates. Specific topics for the eight 1 hour sessions: (i) Research Misconduct (ii) Experimental design and data management practices (iii) Mentor and Trainee Responsibilities; Collaborative Research (iv) Conflicts of Interest; Intellectual property (v) The Protection of Human Subjects (vi) The Welfare of Laboratory Animals (vii) Publication, authorship, and peer review (viii) Peer Review, the Grant Process, and Fiduciary Responsibility. Each Session is ~45 minute lecture with 15 minutes of discussion.
Credits: 0.5 Offered: Fall
This course is required for all first-year graduate students, following NIH mandates. Specific topics for the eight 1 hour sessions: (i) Research Misconduct (ii) Experimental design and data management practices (iii) Mentor and Trainee Responsibilities; Collaborative Research (iv) Conflicts of Interest; Intellectual property (v) The Protection of Human Subjects (vi) The Welfare of Laboratory Animals (vii) Publication, authorship, and peer review (viii) Peer Review, the Grant Process, and Fiduciary Responsibility. Each Session is ~45 minute lecture with 15 minutes of discussion.
Credits: 4 Offered: Fall
This course is a specialized orientation and development program designed for MD-PhD students embarking on training in the Medical Scientist Training Program at the Icahn School of Medicine at Mount Sinai. This academy aims to equip students with a comprehensive toolkit for navigating the multifaceted challenges inherent in the dual-degree pathway. Over four weeks, participants are immersed in a curriculum that intertwines foundational orientation sessions with deep dives into resilience building, leadership skills, and cultivating a robust professional identity.
Credits: 2 Offered: Fall This course offers a practical and comprehensive overview of the most fundamental topics necessary for modern Biomedical Scientists. The course covers key topics essential to the disciplines of Biochemistry & Molecular Biology. This foundational knowledge includes cellular structure, principles of genetics, genome organization, transcription and translation.
Credits: 2 Offered: Fall
The course covers key topics essential to the disciplines of Pharmacology & Drug Discovery. These topics include receptor theory, structure-based drug design, pharmacokinetics and pharmacodynamics, and computational approaches to predict dosing and efficacy.
Credits: 2 Offered: Fall
The course covers key topics essential to the disciplines of Cell & Developmental Biology. These topics include the cytoskeleton, cellular signaling, stem cells, differentiation, and regeneration of damaged organs.
Credits: 2 Offered: Fall
The course covers key topics essential to the discipline of Neuroscience. These topics include systems neuroanatomy, neurophysiology, neurocytology, membrane biophysics, synaptic transmission and plasticity, neuro-immune interactions, degenerative and psychiatric diseases.
Credits: 3 Offered: Fall
The Immunology Core III was developed to provide the students with an in-depth study of the fundamental concepts in Immunology. This is a 45-hour course that it is intended to introduce students to the organization of the immune system and function of the immune response as it relates to health and disease. The different topics and sections will be presented and discussed by faculty members who have expertise in the subject matter. The grades will be based on in-class quizzes and midterm and final exams as well as on class participation. The aim of the course is that students will develop a solid understanding of immunological concepts, develop the skills to help them appreciate immunological research so that they will be prepared to undertake more advanced studies and be able to carry out original research in this field. Reading assignments will be based on Janeway’s Immunobiology textbook (8th edition) and supplementary reading materials suggested by the lecturers. Biomedical Science I and II courses are prerequisites for this course.
Credits: 3 Offered: Fall
The Cellular and Molecular Neuroscience course will provide students with a rigorous foundation in the molecules, cells, and circuits upon which nervous system function is based, how different neural processes are engaged to drive different functions and behaviors, and the nature of brain disorders that affect molecules, cells, and circuits. The course is divided into major relevant themes, each concluding with a theme-based discussion and group presentation focused on critical evaluations of relevant research articles.
Credits: 3 Offered: Fall
This fast-paced, intense course is the first of a 5-part Core course for the Neuroscience PhD track. The goal of this course is to introduce PhD students to different neural circuits. We provide an overview of excitable membranes and synaptic mechanisms for plasticity. We also consider systems for motor behavior, somatosensation, pain, vision, audition and circadian rhythms. Lastly, we discuss neuroendocrine systems and neuroimmune systems. Students must attend lectures in-person and present current literature as a team. Master's students are not permitted by their program to enroll in this course. PhD students in tracks other than Neuroscience must obtain permission from the course Directors to enroll. PhD students who wish to audit this class must attend class, but are not required to take exams, turn in assignments, or present papers.
Credits: 3 Offered: Fall
This course will provide a thorough introduction to invertebrate and vertebrate development with an emphasis on cellular, genetic and molecular mechanisms underlying the generation of diverse cell and tissue types. The course will focus on different model systems, primarily the development of fruit flies, nematodes, Xenopus, zebrafish, and mice, with the goal of building an understanding of fundamental embryological processes, including induction, fate determination, and pattern formation. Knowledge of these processes will also provide a robust foundation for in vitro stem cell differentiation paradigms. Discussion of current technologies and experimental approaches (e.g., transgenic animals, genetics, mosaic analysis, homologous recombination, somatic cell genetics, and classical embryonic manipulations) will be incorporated. Selected topics include: developmental genetics of regulatory hierarchies, lateral inhibition, regeneration and development, cell lineage analysis, X-chromosome inactivation, imprinting, and sex determination. Following introductory lectures, the course will focus on primary literature detailing the current state of the field using journal club presentations (by students). The final exam will consist of grant proposals by the students, to be reviewed by other students in a mock study section.
Credits: 1.5 Offered: Fall
This course focuses on the major neurotransmitter-receptor systems in the brain and the detailed mechanistic underpinnings by which psychotropic drugs (including antipsychotics, antidepressants, anxiolytics, anticonvulsants, drugs of abuse, and others) affect the nervous system. It is designed for students who already have basic knowledge of neuroscience. Each class will involve a student-led discussion of a recent research paper, which illustrates important advanced principles of neuropharmacology and state-of-the-art methods used in the field. Course offered every 2 years.
Credits: 3 Offered: Fall
The purpose of this course is to develop skills to enhance discovery of medically useful drugs.The course uses a case-study approach describing the discovery of the most valuable drugs currently in use, with an emphasis on phenotypic screening, combined with exposure to cuttingedge bioinformatics tools. Some of the drugs to be addressed are penicillin, insulin, the small pox vaccine, ether, morphine, aspirin, salvarsan, thorazine/Haldol, norethindrone, and digoxin. Of particular interest will be assessment of what is, or more generally what is not, known about mechanisms by which drugs exert their therapeutic effects, and how the development of drugs have elucidated mechanisms of disease. Course is offered every 2 years.
Credits: 1 Offered: Fall
With the accelerated development of new technologies and approaches, research at the cutting-edge of neuroscience is fast-evolving. The purpose of this course is to introduce students to current techniques and methodologies used in research labs in the Neuroscience department in order to prepare them for successful rotations in diverse lab settings. Topics covered will include using electrophysiology, viral approaches for cell type-specific manipulations, calcium-based imaging and analysis, modeling ‘disease-in-a-dish’ using stem cells, TRAP and single-nuclei sequencing, and human neuroimaging and large scale data analysis. The course features didactic, discussion, and written components that will facilitate a deep conceptual understanding to enable practical application of popular approaches.
Credits: 1 Offered: Fall
This course will discuss fundamental philosophical assumptions and constructs that are relevant for scientific inquiry, such as - what makes a theory good; what is the construct being studies; what is the purpose of a phenomenon. This course is designed for graduate-level students in the biomedical and neural sciences who are developing foundational thinking for their research interests.
Credits: 2 Offered: Fall
This course enables participants to learn about entrepreneurship and business fundamentals for the process of commercializing biomedical innovation, primarily through the "lean launchpad" method (aka, I-Corp method). Students engage in ideation sessions and then choose to join projects and work in small teams.
From there, the course provides training in relevant business and organizational fundamentals including start-up teams, legal issues, intellectual property strategy, financing, competitive analysis, market intelligence, and marketing or networking towards commercialization of biomedical innovation. Students will conduct key elements of the I-Corp Business Canvas/Lean Launchpad, particularly customer validation, for the project they have joined/led. Student will also get the opportunity to learn how technologies and startups are assessed using some fundamental due diligence methodologies.
The course leverages the impressive expertise in biomedical commercialization found within the Mount Sinai faculty, Mount Sinai Innovation Partners (MSIP), and external advisors to support the course via classroom lectures and extra office hour sessions to support project work. Additionally, we take advantage of Mount Sinai's and NYC's impressive biomedical ecosystem with visits from leading entrepreneurs.
This course may be taken in sequence with the course on Intellectual Property (BSR 2930: Protecting Your Innovation) or just as one course experience (no Pre-requisites are required).
Credits: 0 Offered: Fall
This is a second of two semester courses for those Master's degree students who are planning to attend medical school following completion of their Master's degree. The course continues to provide a detailed educational curriculum, strategic planning and advising about the medical school application process. It consists of information sessions, workshops, and personalized advising. This semester's key topics include detailed writing and review of each components of primary application, personal statement, secondary applications, and mock interviews. Increased individualized support is offered for targeted school selection, personal statement writing, and interview preparations.
Please note, this is uncredited and does NOT appear on your transcript.
Credits: 1.5 Offered: Fall
Please note - Course is offered every other year. Attendance in this course is mandatory.
COMPUTER-AIDED DRUG DESIGN (CADD) is a hands-on course that provides an introduction to computer-aided drug design/discovery technology, including both ligand-based and structure-based rational drug design strategies. Both theoretical and practical aspects of chemoinformatics, virtual screening, and in silico design approaches are presented with the goal of teaching students how to accelerate the discovery of novel molecules with improved therapeutic profiles using modern technologies, including artificial intelligence and machine learning tools. To this end, lectures will be integrated with hands-on sessions and at least one 'serious game' (a.k.a. simulation of a real-world structure-based drug discovery problem).
This course is not only designed to provide students with a solid foundation in computational structural biology, but also to help them become proficient in the use of modern drug discovery solutions available at Mount Sinai (e.g., the Schrödinger's Small Molecule Drug Discovery Suite). Students will also acquire an understanding of how to protect their own intellectual property on discoveries in preclinical stages and how to eventually move these discoveries to commercialization.
Course grade will be a letter grade: Grading will be based on participation (40%) and the successful execution of two "serious games" (30% each).
Prerequisite: Student's basic python skills or prior exposure to another relevant programming language as demonstrated on their undergraduate/graduate academic transcript. In the absence of prior programming experience, successful completion of BMI1007 (Computer Systems: Introduction to Scientific Programming in Python) will be required. The Course Directors will make the final decision as to whether a student's prior experience in programming is sufficient for the course.
Credits: 0.5 Offered: Fall
This semesterly-offered course will aim to inform and instruct students on the process of applying for a predoctoral fellowship. Students will learn the different funding mechanisms available to them for a fellowship and will ultimately prepare several components of the NRSA application with the intent of submission. The subject matter will include strategies for building a highly competitive application by thoroughly analyzing the scored review criteria: Fellowship Applicant; Sponsors, Collaborators, and Consultants; Training Potential; Institutional Environment and Commitment to Training; and Research Training Plan. It will also include strategies for converting a completed Thesis Proposal into the analogous documents for fellowship applications. The course will primarily focus on the application for an NRSA F30/31 award but will be applicable for students targeting other granting mechanisms that have the same components. Homework assignments will aid in the preparation of a fellowship application and will, therefore, keep students on pace for the current submission cycle. Prerequisites: Successfully having passed your Thesis Proposal Exam with the intention to submit a fellowship application by the end of the semester. Grading Policy: Pass/Fall
Credits: 1 Offered: Fall
The course aims to highlight neuroanatomical and molecular mechanisms of drug addiction, with emphasis on clinical applications and novel therapeutic approaches. Clinicians and basic scientists discuss fundamental mechanisms of drug dependence and addiction, novel discoveries, along with clinical cases and reports from physicians or patients. Every lecturer will be joined by 1-2 invited guests that provide a basic science or clinical perspective of the topic. A major goal of the course is to highlight current therapeutic treatments as well as experimental treatments and clinical trials. The class will cover a range of addiction disorders, including opioid and psychostimulant addiction, alchoholism, nicotine addiction and will discuss risk factors for addiction disorders. Students will work with faculty and invited guests to present and discuss.
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
This course uses a journal club format to critically discuss recent literature and the research interests of the students enrolled. Generally, students present a paper from the recent literature relevant to their own research and MTA interests once or twice a year. The goals of journal club are to expand students' breadth of scientific knowledge, practice critically analyzing experimental design, and gain experience and confidence in presenting scientific content to an audience. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Medical Scientist Grand Rounds is a series of joint clinical/scientific presentations that highlight the doctoral work of our senior MD-PhD students. A senior MD-PhD student in their clinical training phase presents the clinical case as an introduction to a scientific topic with the guidance of a clinician expert. The doctoral research presentation focuses the discussion on specific research questions from their dissertation. A panel discussion concludes the session allowing students to simultaneously inquire about the science and medicine.
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
Students are required to give at least one presentation of their ongoing work per year until graduation. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP). All students who have not yet passed the thesis proposal must register for this course. This remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 1 Offered: Fall
The seminar series of each MTA brings leading researchers to ISMMS to discuss their recent research. Starting from Year 1 for NEU students, and beginning in their second year for BMS MTAs (G1 for MSTP), all students who have not yet passed the thesis proposal must register for this course, though this remains a required course by some MTAs and T32 training grants for the duration of the PhD (please check with your MTA directors). Attendance is required; only two unexcused absence is permitted. 1.0 credit (P/F)
Credits: 3 Offered: Fall
Advanced topics in tumor biology is a participatory lecture-based course focusing on cancer diagnosis, therapeutics, genetics,behavioral medicine and ethics. Open to PhD, MSTP and MSBS students.
Credits: 3 Offered: Fall
Students in this course will analyze a human genome sequence starting with raw sequence reads through identifying a list of sequence variants. Using public databases, literature and other resources students will formulate hypotheses about the phenotypic significance of these variants. This is a hands-on, laboratory course in which students will choose to analyze either their own genome or a reference genome after lectures and counseling to make the consequences of personal genome analysis clear.
Credits: 3 Offered: Fall
The purpose of this course is to develop skills to enhance discovery of medically useful drugs. The course uses a case-study approach describing the discovery of the most valuable drugs currently in use, with an emphasis on phenotypic screening, combined with exposure to cutting edge bioinformatics tools. Some of the drugs to be addressed are penicillin, insulin, the small pox vaccine, ether, morphine, aspirin, salvarsan, thorazine/Haldol, norethindrone, and digoxin. Of particular interest will be assessment of what is, or more generally what is not, known about mechanisms by which drugs exert their therapeutic effects, and how the development of drugs have elucidated mechanisms of disease.
Credits: 1 Offered: Fall
The course will cover development, composition, plasticity, and disease related vulnerability of synapses in the central nervous system. The format will be one of discussion and debate surrounding papers in the current literature. Prerequisites: Neuroscience Core or strong neuroscience background
Credits: 2 Offered: Fall
The term hard problem articulates the difficulty of explaining the transition between physical (e.g., neurons) and phenomenal entities (e.g., colors). Thus, why is any merely neural dynamic the basis for any phenomenal experience at all? Alternatively, if we induce some neural dynamic, why does the inductee not merely experience neurons firing, rather than, e.g., seeing phosphenes? I will begin with a brief philosophical overview and move to computational and neurally oriented efforts to address this most central issue of the problem of consciousness.
Credits: 1 Offered: Fall
This course will give students a chance to have detailed discussion of current topics in social neuroscience. We will cover research on social neuroscience in human, non-human primates and rodents, as well as covering both psychological and neurobiological aspects.
Credits: 1 Offered: Fall
The objective of this elective is to provide students with advanced training in an area of interest to them in support of dissertation research and their long-term career development. As part of this elective, students are required to participate in an internship of their choosing and that has prior approval by the student’s dissertation advisor and the course directors. Students are required to provide periodic oral update reports of their progress in the internship (the frequency of these will be determined by the length of the internship) and a final paper summarizing the internship.
Credits: 1 Offered: Fall
The objective of this elective is to provide students with advanced training in an area of interest to them in support of dissertation research and their long-term career development. As part of this elective, students are required to participate in an internship of their choosing and that has prior approval by the student’s dissertation advisor and the course directors. Students are required to provide periodic oral update reports of their progress in the internship (the frequency of these will be determined by the length of the internship) and a final paper summarizing the internship.
Credits: 1 Offered: Fall
The objective of this elective is to provide students with advanced training in an area of interest to them in support of dissertation research and their long-term career development. As part of this elective, students are required to participate in an internship of their choosing and that has prior approval by the student’s dissertation advisor and the course directors. Students are required to provide periodic oral update reports of their progress in the internship (the frequency of these will be determined by the length of the internship) and a final paper summarizing the internship.
Credits: 10 Offered: Fall
Research Credit for Independent Research. Only PhD and MD-PhD in Biomedical Science or Neuroscience, who have NOT passed the Thesis Proposal should register for this course
Credits: 4 Offered: Fall
Research Credit for Independent Research. 1st year Masters in Biomedical Science students should register for this course.
Credits: 4-8 Offered: Fall
Course holder for MSBS students doing 3rd AY for Research only. Research Credit for Independent Research. 2nd year Masters in Biomedical Science students should register for this course for the Fall term 2nd year MSBS students should register for 8 credits of Research, if they plan on completing the degree requirements by December.
Credits: 0 Offered: Fall
This course is open to 3rd year MSBS students who are working full-time in a lab during the Fall semester to complete their master's thesis.
Credits: 3 Offered: Fall
Thesis Credit for MS Biomedical Science. 2nd yr MSBS students should register for this course, only if they are planning to defend and deposit their MS thesis in the upcoming semester.
Credits: 7-10 Offered: Fall
Research Credit for Doctoral Dissertation Research. Only PhD and MD-PhD in Biomedical Science or Neuroscience, who have passed the Thesis Proposal should register for this course
Credits: 0 Offered: Fall
Registration for Biomedical Science and Neuroscience PhD students who have defended, but have not yet deposited their dissertation
Credits: 5 Offered: Spring
All First Year MD/PhD students should register for this course
Credits: 5 Offered: Spring
All Second Year MD/PhD students should register for this course
Credits: 4 Offered: Spring
Laboratory rotations are an important part of the first year of the Graduate Program at Mount Sinai. They give students the opportunity to experience different research projects, different laboratory and mentoring styles, and allow the faculty to assess the interests and aptitude of the students. In general, all PhD and MD/PhD students will complete one-three laboratory rotations (a minimum of two, in two different laboratories, is recommended) before declaring a research preceptor and a Multidisciplinary Training Area. The rotation facilitates the choice of preceptor and also offers students an exposure to problems and techniques of interest to them. For each semester, the student should submit the name of the rotation preceptor and start date of the rotation no later than the beginning of the semester. This is done via the submission of the Rotation Agreement Form.
Credits: 6 Offered: Spring
Biomedical Science - Spring, is part 2 of a year long, six unit course that surveys a broad and comprehensive study of basic Molecular, Cellular and Developmental Biology. The topics covered prepare students for both a career in Biomedical Research, and for the Advanced studies within the CAB, DSCB, GGS, IMM,and MIC MTAs. Biomedical Science is a required course for all first year students that intend to be members of these MTAs. The course is structured as a series of lectures; grade assessment is based on a mixture of in-class and take home quizzes as well as one formal examination per unit. Prerequisite: BSR1012 Biomedical Science - Fall
Credits: 3.5 Offered: Spring
Biomedical Science - Spring for MDPhD students. 1st year MD/PhD students should register for this course.
Credits: 0.5 Offered: Spring
This course is required for all first-year graduate students, and discusses guidelines and considerations to enhancer rigor and reproducibility in biomedical research. Specific Topics to be discussed in nine 1 hour sessions: (i) Experimental Design; (ii) Rigor at the bench; (iii) Validation of Biological and Chemical Reagents; (iv) Open Science and data sharing; (v) Animal Studies; (vi) Behavioral Science; (vii) Human studies and (viii) Review of NIH guidelines, videos and discussion.
Credits: 3 Offered: Spring
This course covers the foundational elements for the collection, analysis, and presentation of data in biomedical research. This course will cover the following topics: general principles of study design including internal and external validity; probability and sampling distributions, theory of confidence intervals and hypothesis testing; review of methods for comparison of discrete and continuous data including one-sample and two-sample tests, correlation analysis, and linear regression. Upon completion of this course, students should have introductory proficiency in statistics to apply their expertise to current biomedical challenges. This course will additionally facilitate important discourse around rigor and reproducibility and introduce students to innovative applications of biostatistics and data science to complex, real-world biomedical research ranging from building predictive algorithms for complex diseases to genetic analysis in ancestrally diverse populations. Diversity and Inclusion Statement: While science is assumed to be objective, the reality is that science is extremely subjective. Science does not exist in a vacuum. Our lived experiences, imbued with varying levels of power and privilege and exclusion and vulnerability over our life course, inform the biomedical problems we choose to explore, our conceptual framework, our methods, and our interpretations of our findings. We are a product of our society as is and as it was in the past. In this course, we must be respectful of others’ identities (i.e., race, gender, class, sexuality, religion, ability, etc.) and perspectives even if they differ from ours. We will address everyone by their preferred names and preferred pronouns. In this course, we will not make assumptions about what someone knows and does not know. We will make knowledge accessible to everyone. In this class, we will grow as scientists and, most importantly, as human beings.
Credits: 0.5 Offered: Spring
This course is required for all first-year graduate students, following NIH mandates. Specific topics for the eight 1 hour sessions: (i) Research Misconduct (ii) Experimental design and data management practices (iii) Mentor and Trainee Responsibilities; Collaborative Research (iv) Conflicts of Interest; Intellectual property (v) The Protection of Human Subjects (vi) The Welfare of Laboratory Animals (vii) Publication, authorship, and peer review (viii) Peer Review, the Grant Process, and Fiduciary Responsibility. Each Session is ~45 minute lecture with 15 minutes of discussion.
Credits: 3 Offered: Spring
This course surveys behavioral and cognitive neuroscience topics including learning and memory, executive function, emotional regulation, and reward processing. A consistent focus is the integration of research findings across species, experimental methods and levels of analysis and evaluation of the quality of experimental findings. The course format includes a didactic component and student presentations of key research articles.
Credits: 3 Offered: Spring
We take a case-based approach to teach contemporary mathematical modeling techniques to graduate students. Lectures provide biological background and describe the development of both classical mathematical models and more recent representations of biological processes. Students are taught how to analyze the models and use computation to generate predictions that may be experimentally tested.
Credits: 3 Offered: Spring
This course will provide students with a deep understanding of cardiovascular and renal physiology. Lectures will both describe both the general functioning of these organ systems and cover selected topics in greater detail. Paper discussion forums and problem sets will complement the material discussed in the lectures. Emphasis will be placed on describing quantitatively the functioning of the heart and kidney, and on illustrating underlying principles that are shared by the two organ systems. Both classical systems-level and contemporary cellular-level issues will be discussed. Topics will include: 1) ionic balance in cardiac cells, 2) multidimensional electrical propagation in heart, 3) systemic control of cardiac output; 4) cotransport of ions and metabolites in renal epithelialcells, and 5) a mathematical description of nephron function.
Credits: 2.5 Offered: Spring
This course covers recent highlights in neurobiological and cognitive deficits in neurological and psychiatric disorders. The goal is to offer students an opportunity to learn about animal models of these disorders directly from experts in the field, with an emphasis on understanding disease mechanisms from molecular, cellular, systems, and cognitive perspectives. In addition, a key feature of this class is that students will write a review paper on the neural and behavioral impairments of a chosen neurological or psychiatric disorder.
Credits: 3 Offered: Spring
This course attempts to recreate in a teaching environment the fundamental approaches of rational small molecule drug discovery research, and teach the fundamental molecular and physico-chemical principles that govern the capacity of small molecules to affect or regulate biological functions of macromolecules. The course consists of three themes, covering topics ranging from lead discovery to drug candidate selection, and to mechanism of action of drugs for both validated and emerging drug target families, as listed below:
Theme #1. Structure-based Drug Discovery
lead discovery and optimization, and drug candidate selection
Theme #2. New Advances on Validated Drug Target Families
drugs and mechanism of action on kinases, GPCRs and others
Theme #3. Emerging Drug Targets
Identification and characterization of drug targets relevant to epigenetics, neurodegenerative diseases and cancer.
Theme #1 teachs the principles of discovery of biological targets and active compounds by hypothesis-driven and high-throughput approaches with both experimental and computational methods. This is followed by characterization of biological target interactions with lead compounds (i.e., structure, energy and dynamics). The inferred molecular mechanisms provide the basis for lead optimization through rational design and medicinal chemistry, and drug candidate selection through evaluation of drug toxicity and efficacy, as well as drug pharmacokinetic/pharmacodynamic properties.
Themes #2 and #3 review the latest advancements in drug discovery for both validated and emerging drug target families consisting of proteins involved in enzymatic catalysis, gene transcription and translation, protein-protein or protein-nucleic acid interactions.
Credits: 3 Offered: Spring
This course will span state of the art genomic approaches for studying human disease. It will include in depth lectures on genomic technologies accompanied by practicals in transcriptomic analysis (RNA-sequencing, scRNA seq, spatial transcriptomics); DNA analysis (exome and whole genome sequencing and interpretation of variants, copy number analyses); Epigenetic, multi-omic and pathway analyses; Haplotypes, and linkage disequilibrium; Human evolutionary trees and signatures of selection; Statistical approaches to analyzing complex traits including quantitative traits; Mendelian randomization and eQTLs; microbiomics. There will also be two day workshops on the UCSC genome browser and how to access public databases such as UK biobank and BioMe.
Credits: 2 Offered: Spring
All scientists have to communicate our science, whether it is to our peers, collaborators, potential funders or the general public. This course aims to provide students with the hands-on skills and knowledge they need to communicate their science effectively. Through a series of hands-on workshops focused on spoken and written skills, students will learn from experts in Policy and Advocacy, Media, Outreach and Teaching to develop their skills. Students will develop the ability to craft a clear message, give and receive feedback and edit their work across a range of media and audiences.
Credits: 2 Offered: Spring
This lecture course, developed jointly between Icahn School of Medicine at Mount Sinai (ISMMS) and Rensselaer Polytechnic Institute (RPI), explores the relationship between academic research, intellectual property, and commercialization. You will learn about the nuances of intellectual property, with a focus on biomedical applications, and how the products of academic research and related innovations can be protected and commercialized. The course will cover experimental design, patent strategy, interaction with regulatory agencies, and the process of starting a company or licensing an invention. Lectures will be given at both RPI and ISMMS by instructors from patent law firms, successful biotech entrepreneurs, and Mount Sinai Innovation Partners.
Credits: 0.5 Offered: Spring
This semesterly-offered course will aim to inform and instruct students on the process of applying for a predoctoral fellowship. Students will learn the different funding mechanisms available to them for a fellowship and will ultimately prepare sev- eral components of the NRSA application with the intent of submission. The subject matter will include strategies for building a highly competitive application by thoroughly analyzing the scored review criteria: Fellowship Applicant; Sponsors, Collaborators, and Consultants; Training Potential; Institutional Environment and Commitment to Training; and Research Training Plan. It will also include strategies for converting a completed Thesis Proposal into the analogous documents for fellowship applications. The course will primarily focus on the application for an NRSA F30/31 award but will be applicable for students targeting other granting mechanisms that have the same components. Homework assignments will aid in the preparation of a fellowship application and will, therefore, keep students on pace for the current submission cycle. Prerequisites: Successfully having passed your Thesis Proposal Exam with the intention to submit a fellowship application by the end of the semester. Grading Policy: Pass/Fall
Credits: 2 Offered: Spring
This intensive international spring course is designed to provide students with the means to understand key concepts and cutting-edge advances in the design of current immunotherapy strategies. We have gathered immunology and immunotherapy experts from around the world to discuss novel perspectives in immunotherapy, review the extraordinary development of novel technology to study the immune system and discuss emerging immunologic paradigms across diseases . The lectures, organized into a 4-day course will be provided online from either France (Sorbonne University or Institut Curie in Paris), Brazil (University of Sao Paulo) or the USA (Mount Sinai, New York) and transmitted live. Lecturers and attendees from all continents will have the opportunity to discuss live in an open forum.
Credits: 2 Offered: Spring
The International Immunotherapy course is a joint initiative between Mount Sinai, Sorbonne University (Paris, FRANCE) and University of Sao Paolo (Sao Paolo, BRAZIL) that recruits leading global experts in the field of immunology and immunotherapies to lecture graduate students and research and clinical fellows. The goal of this class is to provide students with the means to understand the relevance of immunology and immunotherapy strategies in the treatment of human disease. We have gathered an exceptional number of immunotherapy experts throughout the world to teach basic immunology principles and discuss the development and success of different immunotherapies in the treatment of inflammatory diseases, autoimmunity, cancer, and infectious diseases. The course is scheduled over five days and is conducted in real-time via satellite with Brazil and France. Lectures will be provided locally either in France (Sorbonne University/Institut Curie, Paris), in Brazil (University of Sao Paulo) or New York (Mount Sinai) and transmitted live through a videoconference to all three locations. Students and lecturers will have the opportunity to discuss in an open forum. The course is organized in a 1-week module (5hrs/day), and evaluation is based on attendance and participation (2 credits).
Credits: 1 Offered: Spring
The JC in Cancer Biology critically discusses recent literature in the context of each student’s research project. Open to PhD, MDPhD and MSBS students.
Credits: 1 Offered: Spring
This is a Journal Club in Developmental and Stem Cell Biology (DSCB JC). Students will present once a year a paper from the recent literature that is relevant to stem cell biology in developing or adult tissues.
Credits: 1 Offered: Spring
This course is mandatory for 2nd year and above GGS students, and open only to Ph.D. and M.D./Ph.D. students in the GGS MTA. Each week one student will present a paper selected as representing an interesting concept or advance in genetics and genomics. The presenter describes the topic of the paper, summarizing the strengths and weaknesses, followed by an open discussion and critique of the research. For the final 20 minutes, a second presenter gives a progress report about their own work.
Credits: 1 Offered: Spring
This course follows an intensive small group discussion format that critically evaluates original research articles in the area of immunology. The articles are selected by the student in consultation with the presiding faculty member, and include recent important advances in immunology or investigations that provide conceptual advances relating to long-standing problems. The analysis will include background to the research, the hypothesis tested, the experimental methods used, as well as interpretation and discussion of results. This is a discussion class and participation is required. Students are also expected to discuss the implications of the research, the new questions it raises, and how it relates to the rest of the field. Grading will be based on class participation and extent of preparation. This class is required for students beginning in their second year until they complete their Ph.D. First year students interested in immunology are encouraged to attend. Attendance is required for all classes.
Credits: 1 Offered: Spring
This course uses a journal club format to discuss important papers along the interests of the students enrolled. Each student is instructed to carefully select a high impact paper that motivates the work in the lab and lead the discussion of the paper with the group. Active participation from all students is expected. The course meets weekly. All MIC Training Area Graduate students who have not yet completed their thesis proposal are required to take this course.
Credits: 1 Offered: Spring
This one credit journal club course aims to communicate the most exciting ongoing research involving viruses and their molecular interactions with the host, as well as to train students and postdoctoral fellows in the skills of scientific presentation. The course is regularly attended by twenty to thirty research personnel from 10 laboratories, including faculty, postdoctoral fellows, medical students, and graduate students, both from within and outside the MSM Training Area. The course serves as a forum for interdisciplinary communication and discussion of the latest research in the fields of virology, cell biology and immunology. Informed introduction, concise presentation and critical discussion are the themes of the journal club.
Credits: 1 Offered: Spring
Students will present work in progress and are strongly encouraged to have their advisory committee present. Alternatively, students can present a paper with relevance to their lab work. This course meets weekly.
Credits: 1 Offered: Spring
Journal Club in Pharmacological Sciences serves as the main journal club for the Systems Biology of Disease and Therapeutics MTA. The group meets weekly. At each meeting, a student presents a manuscript closely related to his/her dissertation project, and he/she may also present original data, although this is not required. Each paper is chosen by the student presenting that week and is usually related, in a broad sense, to Pharmacology. Topics discussed in the past year have included analysis of data in The Cancer Genome Atlas, identification of targets for treating Marfan Syndrome, and mechanisms underlying the initiation of ventricular arrhythmias.
Credits: 1 Offered: Spring
Students in AIET MTA should register for this course.
This course formalizes the requirement for students in the Artificial Intelligence and Emerging Technologies training area to regularly attend and present in a journal club. The purpose of this journal club is to meet and critically evaluate scientific articles, with one student taking the lead on presenting an article during each meeting. This has three goals: to expand students' breadth of scientific knowledge, to practice critically analyzing experimental design, and (for the presenting student) to gain experience and confidence presenting scientific content to an audience.
Credits: 1 Offered: Spring
Medical Scientist Grand Rounds is a series of joint clinical/scientific presentations that highlight the doctoral work of our senior MD/PhD students. A senior MD/PhD in their clinical training phase presents the clinical case as an introduction to a scientific topic with the guidance of a clinician expert. The doctoral research presentation focuses the discussion on specific research questions from their dissertation. A panel discussion concludes the session allowing students to simultaneously inquire about the science and medicine.
Credits: 1 Offered: Spring
The seminar series in Cancer Biology brings leading researchers to MSSM to discuss their recent research. Open to PhD, MSTP and MSBS students.
Credits: 1 Offered: Spring
Presentations of research by students provide each the opportunity to present their research at least once during the academic year.
Credits: 1 Offered: Spring
Presentation of research by students; each student to present at least once per year
Credits: 1 Offered: Spring
All DSCB students who have not yet passed the Thesis Proposal are required to register for this course.
Credits: 1 Offered: Spring
This is a CME accredited Seminar Series offered by the Department of Genetics and Genomic Sciences and the Institute for Genomics and Multiscale Biology at the Mount Sinai Medical Center. It is open to the entire department and institute, including faculty and trainees. The audience is diverse, with medical geneticists, basic scientists and computational biologists. All GGS students who have not yet passed the Thesis Proposal are required to register for this course.
Credits: 1 Offered: Spring
This forum provides an opportunity for Graduate Students, Postdocs and junior Faculty in the Department of Genetics and Genomic Sciences to present ongoing work to other members of the Department, andgain experience presenting their work publically. After completing their first year rotation projects, each Graduate student is required to give at least one presentation per year. This is a required course for Graduate Students in the GGS MTA from second year until graduation.
Credits: 1 Offered: Spring
This course combines two seminar series hosted by the Immunology Institute at the Icahn School of Medicine at Mount Sinai. The first series features a monthly seminar given by an invited speaker who is a prominent scientist in immunology. Students are expected to familiarize themselves with the speaker’s research areas. Students are expected to attend a luncheon with the speaker which provides them with an opportunity to meet with the speaker and ask questions or engage in discussions. The second series is a weekly work-in-progress seminar presented by students and post-docs on their research.Students will be required to present in this seminar series starting in their 3rd year.
Credits: 1 Offered: Spring
Because of the diverse interests of our faculty, topics for this seminar series range from immunology, virology, bacteriology, oncogenesis, and signal transduction, to molecular biology. Speakers come from all over the United States, Europe,Australia, and Asia. They are from both academic institutions and from industry. The seminar series is attended by faculty from basic science, as well as from clinical departments.
Credits: 1 Offered: Spring
This is the Friedman Brain Institute Translational Neuroscience seminar series. Students in the Neuroscience MTA are required to attend. The seminar provides weekly lectures by outstanding neuroscientists, encompassing all domains of neurobiology, with an emphasis on discovery and translational neuroscience. The seminars will be advertised by e-mail and will be posted on bulletin boards throughout the institution. The seminars are also posted on the FBI website: consult http:// icahn.mssm.edu/research/institutes/brain-institute/events
Credits: 1 Offered: Spring
A series of seminars broadly related to pathophysiology, drug development, and/or systems-level computational analyses.
Credits: 1 Offered: Spring
Students in AIET MTA should register for this course.
This course formalizes the requirement for students in the Artificial Intelligence and Emerging Technologies training area to attend research seminars relevant to their research interests delivered by invited speakers.
Credits: 1 Offered: Spring
Students in AIET MTA should register for this course.
Credits: 3 Offered: Spring
Advanced Topics in Cancer Biology will be offered in the Spring semester, 2014. Three modules will be offered. Students may take either one, two, or all three modules for credit. Each module is 1 credit. This is a journal article-based class in which students take turns leading discussion of assigned journal articles centered on a specific topic and chosen by faculty module leaders. For general information and topics for the coming semester students should contact James Manfredi (8-5495).
Credits: 1 Offered: Spring
Emerging Zika and Ebola viruses caused the two most recent crises in global public health. More and more novel viral threats are discovered and old viral threats are re-emerging. This course will discuss important emerging and re-emerging viruses and their biology, pathogenicity and prevalence. We will also focus on novel prophylactic (vaccines) and therapeutic technologies that are under development to combat these viruses. The course will cover orthomyxoviruses (influenza), paramyxoviruses (Nipah, Hendra etc.), flaviviruses (dengue, Zika etc.), alphaviruses (Chikungunya etc.), bunyaviruses (hantaviruses, CCHFV etc.), filoviruses (Marburg virus, ebolaviruses), coronaviruses (SARS-CoV, MERS-CoV) and others.
Credits: 3 Offered: Spring
The goal of the course is to provide students with a basic understanding of the structural organization and connectivity of the human central and peripheral nervous system. In general, a systems approach is used to review the major sensory, motor and integrated neural systems. Student performance is evaluated by four exams; all students attending the course are expected to take the exams, and the course is open to all interested students
Credits: 0.5 Offered: Spring
This course covers clinical features of major neurologic and psychiatric disorders, including diagnostics, clinical pathology (where appropriate), course of illness, and treatment. The goal is to offer Ph.D. candidates an opportunity to learn more about the disorders they study in laboratory animals, which will improve the translational potential of their work and better prepare them for a future as an NIH-funded investigator. (only available for 1st year Neuroscience MTA PhD students)
Credits: 3 Offered: Spring
The course covers the basic biology of aging, including the genetic and environmental contributions to normal age-related impairment as well as age-related diseases. A particular focus in the role of nutrition in aging, and the relationship between aging and metabolic impairments including obesity and diabetes.
Credits: 3 Offered: Spring
Discussion of issues related to experimental design, and analysis of behavioral and neurophysiological data that are common in systems and behavioral neuroscience studies; with a focus on multilevel modeling and time series analyses. The goals of this course are to: 1) Discuss issues related in experimental design and structure of statistical analysis that tend to occur in the context of behavioral and neurophysiological studies, with specific reference to issues that are likely to be encountered in preparing fellowship applications 2) Get exposure to statistical analysis approaches that are not part of an introductory biostatistics course, including time series analysis 3) Increase fluency with good data analysis practices to generate reproducible data analyses and shareable code This course is designed for students in the Neuroscience PhD program who have already begun to design experiments and collect data. We also will be talking about issues that tend to be encountered in preparing fellowship applications, including how to compose a power analysis that will pass muster in the context of NIH “rigor and transparency” criteria. It is required for Neuroscience PhD students. This course may also be useful for students in other programs (for example, biostatistics) that want an exposure to the types of problems encountered in designing and analyzing experiments in neuroscience. Prerequisites: BSR 1707, 1708 (Neuro Core units 3 and 4) Either: BIO 6400 (Intro to Advanced Biostatistics) OR BSR 1026 (Applied Biostatistics for Biomedical Research) BIO 6300 (Intro to R) highly recommended
Credits: 1 Offered: Spring
The course covers computational methodologies applied to analyze data in the broad fields of bioinformatics and big data mining. Topics covered include machine learning, python scripting, cloud computing, data visualization, full stack deployment, GitHub, and database programming. Students will be required to complete small programming assignments throughout the course. The course will use Jupyter Notebooks to run most tutorials.
Credits: 1 Offered: Spring
The objective of this elective is to provide students with advanced training in an area of interest to them in support of dissertation research and their long-term career development. As part of this elective, students are required to participate in an internship of their choosing and that has prior approval by the student's dissertation advisor and the course directors. Students are required to provide periodic oral update reports of their progress in the internship (the frequency of these will be determined by the length of the internship) and a final paper summarizing the internship.
Credits: 1 Offered: Spring
The objective of this elective is to provide students with advanced training in an area of interest to them in support of dissertation research and their long-term career development. As part of this elective, students are required to participate in an internship of their choosing and that has prior approval by the student's dissertation advisor and the course directors. Students are required to provide periodic oral update reports of their progress in the internship (the frequency of these will be determined by the length of the internship) and a final paper summarizing the internship.
Credits: 10 Offered: Spring
Research Credit for Independent Research. Only PhD and MD/PhD in Biomedical Science or Neuroscience, who have NOT passed the Thesis Proposal should register for this course
Credits: 4 Offered: Spring
Research Credit for Independent Research. 1st year Masters in Biomedical Science students should register for this course.
Credits: 4 Offered: Spring
Research Credit for Independent Research. 2nd year Masters in Biomedical Science students should register for this course for the Spring term
Credits: 0 Offered: Spring
This course is open to 3rd year MSBS students who are working full-time in a lab during the Spring semester to complete their master's thesis. The course is graded Pass/Fail and is 4.5 credits. Tuition is not charged for this course.
Credits: 3 Offered: Spring
Thesis Credit for MS Biomedical Science. 2nd yr MSBS students should register for this course, only if they are planning to defend and deposit their MS thesis in the upcoming semester.
Credits: 7-10 Offered: Spring
Research Credit for Doctoral Dissertation Research. Only PhD and MD/PhD in Biomedical Science or Neuroscience, who have passed the Thesis Proposal should register for this course